Identical twins share shock results after one used Botox for 20 years and the other didn’t

A striking medical study has highlighted just how dramatic the effects of **Botox** can be over the long term. Identical twins participated in the study, but only one began Botox treatments at age 25. Over two decades, the differences between the sisters’ appearances became remarkable.

Botox, the brand name for botulinum toxin, is commonly used to smooth fine lines and wrinkles but also has medical uses for migraines, muscle stiffness, and excessive sweating. The “Botox twin” received injections two to three times a year, focusing on her forehead, frown lines, and occasionally crow’s feet.

Photographs taken in 2006, when the twins were 38, already showed smoother foreheads and fewer eye lines in the treated twin. By 2012, differences were more pronounced: the untreated sister had deeper facial lines, a wider jawline, and puffier features. Both women led healthy lifestyles and used sunscreen, suggesting the contrast was likely due to the treatments, though environmental factors—like differing sun exposure in Los Angeles versus Munich—may have played a role.

Dr. William Binder, who administered the injections, concluded that long-term Botox use can prevent **static wrinkles**, those visible even when the face is at rest, and noted it was well tolerated over 13 years with no adverse effects.

The study’s results were echoed by Dr. Bita Farrell, who experimented on herself by treating only one side of her face. Two weeks later, the Botox-treated side appeared smoother, lifted, and fuller, demonstrating how relaxing downward-pulling facial muscles allows other muscles to create a natural lifting effect.

Experts say this technique can reduce jowls, soften marionette lines, and sharpen the jawline. Together, the twin study and Farrell’s experiment show that Botox, when used consistently over time, can produce **visible, lasting, and natural-looking results**.